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Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort

NCT07485387 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2026-03-20

No results posted yet for this study

Summary

The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are:

Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time?

Participants will:

Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year

This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.

Conditions

  • Mild Cognitive Impairment (MCI)
  • Dementia Alzheimer Type
  • Chronic Pain
  • Depression - Major Depressive Disorder

Sponsors & Collaborators

  • Korea University Anam Hospital

    collaborator OTHER

  • Penn State University

    collaborator OTHER

  • Albert Einstein College of Medicine

    collaborator OTHER

  • Korea University

    lead OTHER

Principal Investigators

  • Sunmi Song · Korea University

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2027-04-30
Completion
2037-12-31

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07485387 on ClinicalTrials.gov