A Study on the Effectiveness of Multidomain Intervention Program for Reducing Risks of Dementia

Summary

Investigators aimed to examine the feasibility and effectiveness of a multidomain intervention strategy involving intensive and maintenance programs aimed at reducing the risk of Alzheimer's disease (AD) in at-risk older adults. Participants were randomly allocated into three groups: (1) intensive plus maintenance program (INT+MNT group), (2) intensive program only (INT-only group), and (3) active control (control group). There were two study hypotheses: 1) the participants in the 4-week intensive program (INT+MNT and INT-only group) would show reduced dementia risk scores compared to control; and 2) that the participants in the added 20-week maintenance program (INT+MNT group) would show greater improvement in dementia risk scores compared to the INT-only and control groups.

Conditions

• Alzheimer Disease

Interventions

BEHAVIORAL

Active control

Control group received a personalized advice on lifestyle modification to prevent dementia and usual care of Community Center for Dementia.

BEHAVIORAL

Intensive + Maintenance program

Both intensive and maintenance program 1. Intensive program The 4-week group-based intensive program was comprised of eight sessions; each session consisted of (1) a 30-min review of the tasks, (2) a 50-min training period, and (3) a 10-min meeting to assign tasks on an individual basis. A study nurse-guided training for modification of vascular risk factors, diet, cognitive and social activity were conducted, And, a physiotherapist conducted an exercise training mainly composed of muscle strengthening and stretching. 2. Maintenance program The allocated study assistants monthly check-up whether participants adhere to the altered habits or not, based on the workbook

BEHAVIORAL

Intensive program only

Only the intensive program was conducted. The 4-week group-based intensive program was comprised of eight sessions; each session consisted of (1) a 30-min review of the tasks, (2) a 50-min training period, and (3) a 10-min meeting to assign tasks on an individual basis. A study nurse-guided training for modification of vascular risk factors, diet, cognitive and social activity were conducted, And, a physiotherapist conducted an exercise training mainly composed of muscle strengthening and stretching.

Sponsors & Collaborators

• Seoul Metropolitan Government

  collaborator OTHER_GOV

• Seoul National University Hospital

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-11-01

Primary Completion

2017-07-31

Completion

2017-07-31

Countries

• South Korea

Study Locations