China Cognition and Aging Study

Summary

The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of dementia and its subtypes in China. It is of great significance to establish a relatively comprehensive national database of cognitive disorders, improve the clinical diagnosis and treatment level of cognitive disorders, and formulate prevention and treatment strategies for dementia. The primary aims of China COAST are as follows:

1. To use the prospective cohort to establish a large database research platform, so as to provide comprehensive epidemiological data, clinical and neuropsychological evaluation data, biological samples, and laboratory tests and imaging data.
2. To update the prevalence and incidence rate of dementia and its subtypes every 2-3 years, and clarify the conversion pattern from normal elderly to MCI and from MCI to dementia.
3. To explore the known or unknown protective and risk factors of dementia and its major subtypes (AD, VaD, other dementia).
4. To discover new pathogenic genes and susceptible genes of dementia and its major subtypes (AD and VaD), as well as new mutation sites of known pathogenic genes. To study the genetic variation, mutation and polymorphism of PSEN1, PSEN2, APP and APOE genes in dementia patients, and to understand their distribution and roles in the pathogenesis.
5. To study the biomarkers (body fluid, genetics, imaging) with diagnostic value of MCI, AD (sporadic and familial) and VaD, to define their cut-off values, and to establish prediction models.
6. To study the diagnostic criteria of cognitive normal, MCI, dementia and their subtypes (clinical and molecular subtypes) in the cohort, and to make psychological assessment scales with high sensitivity and specificity, and in line with the characteristics of Chinese people.
7. To find potentially modifiable risk factors for dementia and to study the prevention and intervention effect of non-pharmacological treatment on APOE ε4 carriers, MCI and AD or other dementia patients，which included improvements in education, nutrition, health care, and lifestyle changes. This needs a long time follow-up.
8. To explore the relationship between dementia as well as its major subtype AD and cerebral and systemetic circulatory disorders (for example, mixed dmentia), as well as potential therapeutic strategies.
9. To carry out investigation and researches about dementia related education, improve the awareness of dementia, and strengthen the management of dementia.
10. To investigate the level of stigma and discrimination and its influencing factors in patients with Alzheimer's disease and their caregivers.

Conditions

• Mild Cognitive Impairment(MCI)
• Alzheimer Disease, Late Onset
• Familial Alzheimer Disease (FAD)
• Vascular Dementia (VaD)
• Normal Control
• Non-Alzheimer Degenerative Dementia

Sponsors & Collaborators

• Beijing Tiantan Hospital

  collaborator OTHER

• Beijing Chao Yang Hospital

  collaborator OTHER

• Fu Xing Hospital, Capital Medical University

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• Peking University First Hospital

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• China-Japan Friendship Hospital

  collaborator OTHER

• Beijing Geriatric Hospital

  collaborator OTHER

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Fujian Medical University Union Hospital

  collaborator OTHER

• Guangzhou Psychiatric Hospital

  collaborator OTHER_GOV

• Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• The Affiliated Hospital Of Guizhou Medical University

  collaborator OTHER

• Handan Central Hospital

  collaborator OTHER

• Hebei General Hospital

  collaborator OTHER

• First Hospital of Shijiazhuang City

  collaborator OTHER

• Tangshan Worker's Hospital

  collaborator OTHER

• Hunan Provincial People's Hospital

  collaborator OTHER

• Kaifeng Central Hospital

  collaborator OTHER

• People's Hospital of Zhengzhou University

  collaborator OTHER

• Zhongnan Hospital

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• People's Hospital Affiliated Hubei Medical University

  collaborator UNKNOWN

• The Third Xiangya Hospital of Central South University

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• China-Japan Union Hospital, Jilin University

  collaborator OTHER

• Subei People's Hospital of Jiangsu

  collaborator UNKNOWN

• Nantong University Affiliated Hospital

  collaborator UNKNOWN

• Mineral General Hospital, Xuzhou

  collaborator UNKNOWN

• Jiangxi Provincial People's Hopital

  collaborator OTHER

• Anshan Central Hospital

  collaborator OTHER

• Affiliated Zhongshan Hospital of Dalian University

  collaborator OTHER

• First Hospital of China Medical University

  collaborator OTHER

• Baotou Central Hospital

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• The People's Hospital of Ningxia

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• The 960th Hospital of PLA

  collaborator UNKNOWN

• Qilu Hospital of Shandong University

  collaborator OTHER

• Qilu Hospital of Shandong University (Qingdao)

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Qingdao Municipal Hospital

  collaborator OTHER

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Tang-Du Hospital

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Shanghai Changzheng Hospital

  collaborator OTHER

• Affiliated Hospital of North Sichuan Medical College

  collaborator OTHER

• Tianjin Huanhu Hospital

  collaborator OTHER

• Tianjin Medical University General Hospital

  collaborator OTHER

• Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region

  collaborator UNKNOWN

• Ningbo Medical Center Lihuili Hospital

  collaborator OTHER_GOV

• First Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• First Affiliated Hospital of Zhejiang University

  collaborator OTHER

• Shao Yifu Hospital of Zhejiang Medical University

  collaborator UNKNOWN

• Zhejiang Provincial People's Hospital

  collaborator OTHER

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• People's Hospital of Chongqing

  collaborator OTHER

• Dongfang Hospital Beijing University of Chinese Medicine

  collaborator OTHER

• Zigong No.1 Peoples Hospital

  collaborator OTHER

• Capital Medical University

  lead OTHER

Principal Investigators

• Jianping Jia, Doctor · Xuanwu Hospital of Capital Medical University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2000-01-01

Primary Completion

2038-01-01

Completion

2038-01-01

Countries

• China

Study Locations