Nosocomial Pneumonia After Coronary Artery Bypass Grafting

Summary

Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery.

This is Prospective, cohort, unblinded, observational comparable single center clinical trial. To compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients with coronary artery bypass grafting with and without non-ventilator-associated postoperative, nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis.

Increased risk of cardiovascular outcomes is related with the circulatory arrest, artificial circulation, perioperative trauma and respiratory complications of the postoperative period associating to the different severity and duration of the systemic inflammatory response, immune status disorders, hemostasis disorder, endothelial dysfunction, external respiration dysfunction, anatomic and functional disorders in the heart and lungs. Individual predictors of an unfavorable prognosis can be determined at the stage of before and just after surgery to conduct personalized prevention.

This study aimed to compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients after coronary artery bypass grafting with and without non-ventilator-associated postoperative nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis.

Conditions

• Coronary Artery Disease
• Pneumonia Nosocomial

Interventions

OTHER

Clinical, laboratory, and instrumental examination

Clinical, laboratory, and instrumental examinations will be performed to achieve the specified primary and secondary endpoints.

Sponsors & Collaborators

• Tomsk National Research Medical Center of the Russian Academy of Sciences

  lead OTHER

Principal Investigators

• Alla A. Boshchenko, MD, PhD · Cardiology Research Institute of Tomsk NRMC

• Tatiana P Kalashnikova, MD, PhD · Cardiology Research Institute of Tomsk NRMC

• Irina V. Kologrivova, MD, PhD · Cardiology Research Institute of Tomsk NRMC

• Natalia V. Rebrova, MD, PhD · Cardiology Research Institute of Tomsk NRMC

• Arina S Zinovieva, MD · Cardiology Research Institute of Tomsk NRMC

• Ulia A Arseneva, MD · Cardiology Research Institute of Tomsk NRMC

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-10-01

Primary Completion

2026-06-30

Completion

2027-06-30

Countries

• Russia

Study Locations