MedTrace Logo

AEROBIC ADAPTATION AND BIOMARKER RESPONSES IN COMBAT ATHLETES

NCT07473440 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-03-16

No results posted yet for this study

Summary

This randomized controlled study investigates the effects of sport-specific training on aerobic adaptation and circulating biomarker responses in trained combat athletes. Exercise induces systemic physiological adaptations through signaling molecules known as exerkines, including myokines and adipokines, which mediate communication between skeletal muscle and other metabolic organs.

Forty trained male kickboxers are randomly assigned to either an experimental training group or a control group. The experimental group performs an eight-week sport-specific conditioning program in addition to regular technical training, while the control group maintains their usual training routine.

Aerobic capacity is assessed using maximal oxygen uptake (VO₂max). Blood samples are collected before and after the intervention to determine circulating levels of exercise-responsive biomarkers, including myostatin, irisin, apelin, brain-derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF21), and adiponectin.

The primary objective of the study is to evaluate whether changes in circulating biomarker responses are associated with improvements in aerobic performance. The findings may provide insight into the molecular mechanisms underlying exercise-induced physiological adaptation in combat athletes.

Conditions

  • Exercise Adaptation
  • Aerobic Capacity
  • Athletic Performance
  • Combat Sports Training

Interventions

BEHAVIORAL

SPORT-SPECIFIC CONDITIONING PROGRAM

PARTICIPANTS PERFORMED AN EIGHT-WEEK SPORT-SPECIFIC CONDITIONING PROGRAM DESIGNED TO IMPROVE AEROBIC CAPACITY. TRAINING SESSIONS WERE CONDUCTED THREE TIMES PER WEEK AND CONSISTED OF REPEATED HIGH-INTENSITY INTERVALS INTERSPERSED WITH SHORT RECOVERY PERIODS, REFLECTING THE PHYSIOLOGICAL DEMANDS OF COMBAT SPORTS.

Sponsors & Collaborators

  • Adiyaman University

    lead OTHER

Principal Investigators

  • Eren Bozyılan · Adiyaman University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-20
Primary Completion
2025-03-20
Completion
2025-03-25

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07473440 on ClinicalTrials.gov