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Effects of Aerobic and Resistance Exercise on Cardiovascular Biomarkers in Sedentary Women

NCT07457047 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-03-09

No results posted yet for this study

Summary

This randomized controlled trial investigated the effects of aerobic and resistance exercise on cardiovascular and inflammatory biomarkers in sedentary young women. Forty-five healthy sedentary females aged 18 to 25 years were randomly assigned to aerobic exercise, resistance exercise, or control groups. The exercise groups trained three times per week for 8 weeks under supervision, while the control group maintained a sedentary lifestyle. Blood samples and physiological measurements were obtained at baseline and after the intervention. The primary aim was to evaluate changes in circulating natriuretic peptides and inflammatory biomarkers, including NT-proBNP, BNP, soluble ST2, and Galectin-3. Secondary outcomes included lipid profile, glucose and insulin levels, blood pressure, and aerobic fitness. The study examined whether different exercise modalities induce beneficial cardiometabolic adaptations in previously sedentary young women.

Conditions

  • Sedentary Lifestyle
  • Cardiometabolic Risk

Interventions

BEHAVIORAL

Aerobic Exercise Training

Supervised treadmill-based moderate-intensity walking and jogging at 60-75% of heart rate reserve, 60 minutes per session including warm-up and cool-down, three sessions per week for 8 weeks.

BEHAVIORAL

Resistance Exercise Training

Supervised whole-body resistance training including major muscle group exercises, performed as 3 sets of 8-10 repetitions at approximately 70-80% of one-repetition maximum, three sessions per week for 8 weeks.

Sponsors & Collaborators

  • Ondokuz Mayıs University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-22
Primary Completion
2023-11-23
Completion
2025-05-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07457047 on ClinicalTrials.gov