MedTrace Logo

Apical Preparation Size in Regenerative Endodontics of Mature Teeth

NCT07466433 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-03-12

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether the size of apical preparation affects the success of regenerative endodontic treatment in mature permanent teeth with apical periodontitis. Regenerative endodontic treatment is a procedure that aims to eliminate infection and support healing of the tissues around the root of the tooth.

The main questions the study aims to answer are:

* Does a larger apical preparation improve healing around the root tip?
* Does apical preparation size affect pain after treatment or recovery of tooth vitality?

Researchers compared two treatment approaches that use different apical preparation sizes to see if one leads to better clinical and radiographic healing.

Participants:

* Received regenerative endodontic treatment with one of two apical preparation sizes
* Attended follow-up visits for clinical examination and radiographic evaluation
* Were monitored for pain and healing outcomes during the follow-up period

Conditions

  • Apical Periodontitis
  • Mature Teeth
  • Regenerative Endodontic Treatment

Interventions

PROCEDURE

Regenerative Endodontic Treatment

Regenerative endodontic treatment (RET) is a biologically based procedure that includes root canal disinfection followed by placement of a biological scaffold to support tissue regeneration and periapical healing. In this study, the intervention differs according to the apical preparation size used (ISO 40 and ISO 80) in mature teeth with apical periodontitis.

Sponsors & Collaborators

  • Marmara University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-29
Primary Completion
2025-10-23
Completion
2025-10-23

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07466433 on ClinicalTrials.gov