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Effect of Different Apical Actions on Local Inflammatory Mediators and Pain

NCT06760312 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2025-07-16

No results posted yet for this study

Summary

The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process. The main questions it aims to answer are:

1. How the different apical actions of endodontic motors influence the pain and inflammatory mediator release from the periapical region of related tooth?
2. Does the perceived pain differ among the used apical action methods after the root canal preparation?
3. Are the perceived pain and local pain mediator levels coherent?

Participants will:

Attend to the root canal treatment in the endodontics clinic. The treatment will be two visits.

Answer the Visual Analog Scale questionnaire on day 0 (first appt.) and Day 3 (second appt.) Keep a diary of their symptoms and the number of times they use an anti-inflammatory drug.

Conditions

  • Postoperative Dental Pain
  • Pulp Disease, Dental
  • Pulpitis - Irreversible

Interventions

PROCEDURE

Root canal shaping with Continuous Rotation

The root canal shaping is conducted with a continuous rotation kinematic.

PROCEDURE

Root canal shaping with Apical Reverse

The root canal shaping is conducted with a apical reverse kinematic.

PROCEDURE

Root canal shaping is conducted with Apical slow-down kinematic.

The root canal shaping is conducted with a apical slow-down kinematic.

Sponsors & Collaborators

  • Izmir Katip Celebi University

    lead OTHER

Principal Investigators

  • Emrah Karataşlıoğlu, PhD · İzmir Katip Çelebi Üniversitesi

  • Mustafa Mert Tulgar, Dmd · İzmir Katip Çelebi Üniversitesi

  • Yağmur Kılıç, Dmd · İzmir Katip Çelebi Üniversitesi

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
49 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-02-01
Primary Completion
2025-05-01
Completion
2025-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06760312 on ClinicalTrials.gov