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Lesion Healing After Regenerative Endodontic Treatment

NCT06843850 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-02-25

No results posted yet for this study

Summary

Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies. Root canal treatment, a widely performed procedure, involves removing necrotic pulp tissue and replacing it with a root-filling material, but it limits the tooth's immune defense and regenerative capacity. In immature permanent teeth, pulpal damage can lead to incomplete root formation, increasing the risk of fractures. To address these challenges, regenerative endodontic procedures (REPs) promote tissue regeneration within the root canal using tissue engineering principles.

Despite high success rates, REPs lack a standardized irrigation protocol. Current guidelines recommend using 17% EDTA after low-concentration NaOCl to reduce cytotoxicity and release bioactive molecules. Citric acid has shown promise in in vitro studies as an alternative chelating agent, but direct comparisons with EDTA in clinical settings remain limited. This study aims to bridge this gap by evaluating the long-term effects of EDTA and citric acid on clinical symptoms and lesion healing in REPs.

Conditions

  • Apical Periodontitis

Interventions

DEVICE

regenerative endodontics

The effect of different irrigation solutions on lesion healing in regenerative endodontics will be compared.

Sponsors & Collaborators

  • TC Erciyes University

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
9 Years
Max Age
15 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2024-03-01
Completion
2024-12-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06843850 on ClinicalTrials.gov