MedTrace Logo

Acute Sarcopenia in Hospitalized Older Adults

NCT07454759 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 280

Last updated 2026-03-06

No results posted yet for this study

Summary

Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult. Current standard of care lacks systematic strategies for its early detection and risk stratification. This study therefore proposes to combine established clinical and instrumental assessments (handgrip dynamometry, bioelectrical impedance analysis, ultrasound of the anterior thigh) to better characterize the risk factors, and outcomes of acute sarcopenia in hospitalized patients aged 65 years or older.

The study hypothesis is that the use of a systematic objective clinical assessments will improve early detection and risk stratification of this condition and the detection of acute sarcopenia related outcomes.

This is a prospective observational cohort study that will be conducted in the Emergency Department and Medical Wards of the San Raffaele Hospital.

Studies objectives will include:

* Determination of the incidence of acute sarcopenia
* Identification of clinical and demographic risk factors for acute sarcopenia and relevant clinical outcomes associated with this condition

Conditions

Interventions

DIAGNOSTIC_TEST

Acute sarcopenia will be defined as the incidence of sarcopenia compared to baseline measurements at recruitment, using the European Working Group on Sarcopenia in older people 2 (EWGSOP2) criteria

The study procedures include: * Handgrip dynamometry to evaluate muscle strength using a standardized dynamometer. * Bioelectrical impedance analysis (BIA) and ultrasound of the anterior thigh to measure muscle mass. No comparator procedure is foreseen. The regimen includes baseline assessment within 24 hours of admission, repeated evaluations on days 3, 5, 7, 10, and every five days until discharge (on average maximum 20 days after hospital admission), with follow-up visits at 3 and 6 months post-discharge.

Sponsors & Collaborators

  • Società Italiana di Medicina Interna

    collaborator OTHER

  • IRCCS San Raffaele

    lead OTHER

Principal Investigators

  • Sarah Damanti, MD, PhD · IRCCS Ospedale San Raffaele

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2027-05-01
Completion
2027-05-01

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07454759 on ClinicalTrials.gov