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Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults

NCT07453537 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2026-03-06

No results posted yet for this study

Summary

This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2/Hypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3/Hypothesis 3).

Conditions

  • Stress Response
  • Mental Stress
  • Multitasking Behavior and Multitasking Ability
  • Physiological Stress
  • Cognitive Symptoms
  • Motor Activity

Interventions

OTHER

Cranberry juice

Participants will consume the cranberry juice beverage by mouth each day for 70 days following a run-in period.

OTHER

Placebo juice

Participants will consume the placebo cranberry juice beverage by mouth each day for 70 days following a run-in period.

Sponsors & Collaborators

  • University of Florida

    lead OTHER

Principal Investigators

  • Lewei Gu, PhD · University of Florida

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2028-05-01
Completion
2029-08-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07453537 on ClinicalTrials.gov