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Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy

NCT07450690 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-03-05

No results posted yet for this study

Summary

The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults.

The main questions it aims to answer are:

* How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy?
* How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy?

Researchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups.

The participants will:

* Complete a 3-4-week supervised exercise training program using one leg.
* Undergo muscle biopsies from both the trained and untrained leg.
* Complete basic muscle strength and physical function tests.

Conditions

  • Mitochondrial Diseases
  • Mitochondrial Myopathy

Interventions

BEHAVIORAL

Unilateral high-intensity interval training (HIIT)

Participants will undergo ten sessions of HIIT of the leg randomized to the intervention while the inactive leg serves as the control leg

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    collaborator OTHER

  • University of Copenhagen

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-09
Primary Completion
2026-10-30
Completion
2030-10-30

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07450690 on ClinicalTrials.gov