Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy

Summary

The goal of the study is to determine whether aerobic or resistant exercise can improve in vivo mitochondrial capacity of skeletal muscle cells similarly in healthy younger, middle aged and older adults. This confers long-term changes in this tissue which in-turn contribute to improved metabolic health and functional capacity through epigenetic regulation of novel exercise response genes.

Conditions

• Physical Activity

Interventions

OTHER

Isometric Contraction Exercise - Young Adults (Age group 18-39)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

OTHER

Isometric Contraction Exercise - Middle Age Adults (Age group 40-59)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

OTHER

Isometric Contraction Exercise - Old Adults (Age group >60)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

Sponsors & Collaborators

• University of Colorado, Denver

  collaborator OTHER

• University of Pittsburgh

  collaborator OTHER

• The University of Texas Health Science Center at San Antonio

  collaborator OTHER

• AdventHealth Translational Research Institute

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Wake Forest University Health Sciences

  collaborator OTHER

• Pennington Biomedical Research Center

  lead OTHER

Principal Investigators

• Owen T Carmichael, PhD · Director, Biomedical Imaging Center, PBRC

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-08-02

Primary Completion

2025-05-12

Completion

2025-05-12

Countries

• United States

Study Locations