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The Practicality and Utility of Measured vs Estimated GFR in adCKD

NCT07450534 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-03-04

No results posted yet for this study

Summary

The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis.

The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods.

In addition to routine care, participants will:

* undergo a brief clinical assessment
* be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back
* be asked to complete a questionnaire on their experience

Conditions

  • Chronic Kidney Disease (Stages 4 and 5)
  • Chronic Kidney Disease 5D

Interventions

DIAGNOSTIC_TEST

Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)

Injection of 3235mg iohexol (equivalent to 5ml Omnipaque 300) followed by serial dried blood spot testing over 24 hours to be measured for iohexol concentration and used to calculate clearance.

Sponsors & Collaborators

  • Manchester University NHS Foundation Trust

    lead OTHER_GOV

Principal Investigators

  • Thomas Lindsay · Manchester University NHS Foundation Trust

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-28
Primary Completion
2026-09-30
Completion
2027-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07450534 on ClinicalTrials.gov