Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients

Summary

This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma (LMS), synovial sarcoma (SS), vascular sarcomas, malignant peripheral nerve sheath tumour (MPNST) or other subtypes. It comprises of both retrospective and prospective tissue collection from patients advancing directly to surgery (control group) and patients receiving NCT and surgery.

Conditions

• Sarcoma
• Sarcoma, Leiomyo-, Adult
• Sarcoma, Synovial, Adult
• Soft Tissue Sarcoma (STS)
• Soft Tissue Sarcoma Adult
• Soft Tissue Sarcoma of the Trunk and Extremities
• Soft Tissue Sarcoma of the Limb
• Retroperitoneal Sarcoma
• Liposarcoma, Dedifferentiated
• Liposarcoma
• Leiomyosarcoma (LMS)
• Angiosarcoma

Interventions

OTHER

Observational Translational Study

Cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT)

Sponsors & Collaborators

• Institute of Cancer Research, United Kingdom

  collaborator OTHER

• University of Edinburgh

  collaborator OTHER

• NHS Greater Glasgow and Clyde

  collaborator OTHER

• University of Birmingham

  collaborator OTHER

• University Hospital Birmingham

  collaborator OTHER

• Cancer Research UK

  collaborator OTHER

• Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

  collaborator OTHER

• Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

  collaborator OTHER

• Hospitales Universitarios Virgen del Rocío

  collaborator OTHER

• Andalusian Network for Design and Translation of Advanced Therapies

  collaborator OTHER

• Instituto de Biomedicina de Sevilla

  collaborator UNKNOWN

• the Fundación Científica de la Asociación Española Contra el Cáncer

  collaborator UNKNOWN

• Associazione Italiana per la Ricerca sul Cancro

  collaborator OTHER

• Freeman Hospital, UK

  collaborator UNKNOWN

• Liverpool Hospital

  collaborator UNKNOWN

• The Clatterbridge Cancer Centre NHS Foundation Trust

  collaborator OTHER

• Royal Marsden NHS Foundation Trust

  lead OTHER

Principal Investigators

• Robin Jones, MD · Royal Marsden NHS Foundation Trust

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-11-19

Primary Completion

2026-03-31

Completion

2028-06-30

Countries

• United Kingdom

Study Locations