Gene Signatures Searching of Sensitivity/Resistance to Neoadjuvant Radiotherapy in Patients With Resectable STS
NCT05739084 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300
Last updated 2023-02-22
Summary
To date, the radiation oncologist are missing biomarkers predictive of response/resistance to RT in order to identify patients who may benefit from RT and personalize the RT schedule. Our proposal is to conduct a cohort study aiming at identifying transcriptomic biomarkers predictive of sensitivity and/or resistance to RT in limbs STS patients
Conditions
- Soft Tissue Sarcomas
Interventions
- RADIATION
-
pre-operative radiation
As per standard of care and institutional guidelines
- PROCEDURE
-
Standard surgery after rpreoprative radiation
As per standard of care and institutional guidelines
Sponsors & Collaborators
-
Centre Leon Berard
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-11-23
- Primary Completion
- 2025-06-23
- Completion
- 2025-11-23
Countries
- France
Study Locations
More Related Trials
-
The Total Neoadjuvant Therapy for Soft Tissue Sarcoma of the Extremities
NCT06593899 ·Status: RECRUITING ·Phase: PHASE2
-
Study of the Efficacy of SBRT on Unresectable Peripheral Primary Tumor
NCT02400424 ·Status: TERMINATED ·Phase: NA
-
Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma
NCT06980259 ·Status: RECRUITING ·Phase: NA
-
5-Day Preoperative Radiation for Soft Tissue Sarcoma
NCT06087861 ·Status: RECRUITING ·Phase: PHASE2
-
Stereotactic Body Radiation Therapy for Inoperable Locally-advanced Non-small Cell Lung Cancer
NCT01899989 ·Status: COMPLETED ·Phase: PHASE1
-
Prospective Study on Factors Predicting Chemo-Radiotherapy Induced Pulmonary and Esophageal Injury
NCT00631839 ·Status: UNKNOWN
-
SMC Radiation Oncology SABR Cohort for Oligometastasis
NCT07121335 ·Status: RECRUITING
-
Study of the Decrease of Length of Stereotactic Body Radiation Therapy in Lung Cancer
NCT03921957 ·Status: UNKNOWN ·Phase: NA
-
Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma
NCT06905132 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer
NCT02136355 ·Status: COMPLETED ·Phase: NA
-
Study Evaluating the Safety and Efficacy of MEDI5752 in Combination With Stereotactic Radiotherapy in Patients With Metastatic Sarcoma
NCT05821231 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients
NCT01734863 ·Status: WITHDRAWN ·Phase: PHASE3
-
Radiation Therapy Before Surgery for Localized, Resectable Soft Tissue Sarcoma of the Extremity and Superficial Trunk
NCT04562480 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma
NCT02787642 ·Status: COMPLETED ·Phase: PHASE1
-
Stereotactic Body Radiation Therapy in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Can Be Removed By Surgery
NCT00551369 ·Status: COMPLETED ·Phase: PHASE2
-
Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients
NCT02275286 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Application of Medical Imaging Procedures in Surgery Implanting in Cancerology With the Aim to Reduce Invasive Acts
NCT00925509 ·Status: TERMINATED ·Phase: NA
-
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc)
NCT03548428 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Toxicity of SCART
NCT06341257 ·Status: WITHDRAWN ·Phase: NA
-
Stereotactic Radiosurgery in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer
NCT00852644 ·Status: TERMINATED ·Phase: NA
-
Prevention of Radiation Pneumonitis After Three-dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-small-cell Lung Cancer
NCT00349102 ·Status: COMPLETED ·Phase: PHASE3
-
Survival Efficacy of Combined Radiotherapy and Immunotherapy in Patients With Metastatic Non-small Cell Lung Carcinoma
NCT07111104 ·Status: COMPLETED
-
Investigating the Tumour Immune Response of Radiotherapy
NCT05076500 ·Status: RECRUITING
-
A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.
NCT06022159 ·Status: RECRUITING ·Phase: PHASE2
-
A Platform of Patient Derived Xenografts (PDX) and 2D/3D Cell Cultures of Soft Tissue Sarcomas (STS)
NCT02910895 ·Status: RECRUITING ·Phase: NA