A first-in-human T-cell therapy showed lasting benefit in children with DIPG and relapsed CNS tumors, while a preclinical mRNA vaccine reduced neuroblastoma tumor size by 70%. Aneuploidy predicted response to olaparib plus irinotecan.
China's 12th national Volume-Based Procurement round places RMB 60 billion across 65 drug varieties, accelerating generics and biosimilars substitution. Separately, Genialis launched BioBridge to help translate Chinese oncology trial results into Western development programs, as Chinese out-licensing hit $137.7 billion in 2025.
Researchers have identified how the MYC protein helps pancreatic cancer evade immune detection, while a separate team discovered methods to permanently switch off cancer genes in leukemia through epigenetic therapy targeting Menin and DOT1L proteins.
Scientists at UC San Diego have identified N4BP2 as the enzyme responsible for chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers that enables rapid tumor evolution and treatment resistance.
Research shows TET2-driven clonal hematopoiesis improves immune checkpoint blockade efficacy in solid tumors, while separate studies identify new immune pathways in childhood brain cancers and mechanisms behind immunotherapy resistance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07776353 |
Understanding New Cachexia Subtypes Through Observational Epidemiological Research |
RECRUITING | |
| NCT07751133 |
Evaluating Hormone Therapy to Achieve Optimal Doses in Metastatic Prostate Cancer |
NOT_YET_RECRUITING | PHASE3 |
| NCT07721740 |
Using Patient Navigation to Promote Bowel Screening in AAA Attendees. |
NOT_YET_RECRUITING | NA |
| NCT07649525 |
Personalising Treatment for Myeloma Patients Based on Initial Response to NHS Treatment and Their Overall Fitness Level |
RECRUITING | PHASE3 |
| NCT07440290 |
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. |
RECRUITING | PHASE2/PHASE3 |
| NCT07432932 |
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients |
RECRUITING | |
| NCT07391215 |
5G-PEARL: Paxalisib in Malignant Brain Tumours |
RECRUITING | PHASE1/PHASE2 |
| NCT07279454 |
The EAT-FIBRE Study. |
NOT_YET_RECRUITING | NA |
| NCT07209774 |
Healthspan Connect Programme of Research |
NOT_YET_RECRUITING | |
| NCT07172958 |
Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) |
RECRUITING | PHASE1 |
