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Pulmonary and Total Blood Volume in COPD

NCT07428785 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2026-02-24

No results posted yet for this study

Summary

Background Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death. This is markedly affected by a reduced exercise capacity and dyspnoea, but the underlying mechanisms are unknown. In the present study, we aim to investigate whether this may involve a reduced pulmonary blood volume secondarily to a reduced total blood volume.

Methods Design: Prospective matched comparative study Intervention: None

Outcomes:

The primary outcome is pulmonary blood volume estimated to total blood volume ratio between patients with COPD and healthy controls individually matched for age, sex, and height.

Statistical design:

All statistical analyses will be performed using R statistical software version 4.1.1 (R Project for Statistical Computing) within RStudio statistical software version 1.4.1717 (RStudio), and a two-tailed p\<0.05 will be considered statistically significant. Inspection of normality and variance homogeneity will be done by creating qq-plots and histogram.

Regulatory considerations: This study will be submitted for approval by Regional Ethical Committee.

Perspective: This study will help uncover fundamental aspects of the pathophysiology of COPD.

Conditions

  • COPD (Chronic Obstructive Pulmonary Disease)
  • Healthy Subjects

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Ronan MG Berg, MD, DMSc · Center for Aktiv Sundhed, rigshospitalet

Eligibility

Min Age
45 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-15
Primary Completion
2026-12-20
Completion
2026-12-20

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07428785 on ClinicalTrials.gov