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Pressure Targeting During High Flow Therapy in Premature Infants

NCT07418502 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2026-02-18

No results posted yet for this study

Summary

The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants. It will also learn about the effect of these types of breathing support on infant comfort and impact on staffing. The main question it aims to answer is:

Does Pressure Targeted High Flow provide enough support in premature infants?

Participants will:

Take spend 24 hours supported by Pressure Targeted High Flow and 24 hours supported by CPAP. During this time their breathing rate, oxygen requirement and other markers of comfort will be monitored.

Conditions

  • Preterm Infants
  • Respiratory Distress Syndrome (Neonatal)
  • BPD - Bronchopulmonary Dysplasia

Interventions

PROCEDURE

Pressure Targeted High Flow

High Flow Nasal Cannula therapy with Pressure monitoring to match delivered CPAP pressure

PROCEDURE

CPAP

Standard of care CPAP therapy

Sponsors & Collaborators

  • Sharp Mary Birch Hospital for Women & Newborns

    collaborator OTHER

  • University of Texas at Austin

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
7 Days
Max Age
40 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2027-08-31
Completion
2027-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07418502 on ClinicalTrials.gov