Nasal Intermittent Positive Pressure Ventilation(NIPPV) vs Continuous Positive Airway Pressure for Respiratory Distress Syndrome

Summary

In the past, several studies have compared the effects between nasal intermittent positive pressure ventilation(NIPPV) and nasal continuous positive airway pressure(NCPAP) on the incidence of intubation in preterm infants, and the results were inconsistent.The purpose of the present study was to compare NIPPV with NCPAP on the need for endotracheal ventilation and subsequent complications

Conditions

• Nasal Intermittent Positive Pressure Ventilation
• Nasal Continuous Positive Airway Pressure

Interventions

DEVICE

NIPPV

NIPPV is used as a primary mode of ventilation in premature infants with respiratory distress syndrome

DEVICE

NCPAP

NCPAP is used as a primary mode of ventilation in premature infants with respiratory distress syndrome

Sponsors & Collaborators

• Guiyang Maternity and Child Health Care Hospital

  collaborator OTHER

• Children's Hospital of Chongqing Medical University

  collaborator OTHER

• Chongqing Maternal and Child Health Hospital

  collaborator OTHER

• Yan'an Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• The Children's Hospital of Zhejiang University School of Medicine

  collaborator OTHER

• Chengdu Women's and Children's Central Hospital

  collaborator OTHER

• Kunming Children's Hospital

  collaborator OTHER

• Shanxi Provincial Maternity and Children's Hospital

  collaborator OTHER

• Children's Hospital of Fudan University

  collaborator OTHER

• Guangdong Women and Children Hospital

  collaborator OTHER

• Nanjing Children's Hospital

  collaborator OTHER

• Jiulongpo No.1 People's Hospital

  collaborator OTHER

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

  lead OTHER

Principal Investigators

• Shi Yuan, PhD,MD · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

5 Minutes

Max Age

6 Hours

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-08-01

Primary Completion

2020-07-30

Completion

2020-07-30

Countries

• China

Study Locations