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IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols

NCT07409493 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 148

Last updated 2026-02-13

No results posted yet for this study

Summary

The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:

* Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol?
* Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging?
* How does embryo quality (KIDScore) compare between the two protocols?

Study Design:

Researchers will randomly assign 148 women undergoing IVF to two groups:

* PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle
* GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm

Participants will:

* Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days
* Have regular ultrasound monitoring and blood tests to track follicle development
* Undergo egg retrieval procedure when follicles are mature
* Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring
* Have embryos frozen on Day 5/6 for future transfer

Study Location:

Department of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital

Study Duration: January 2026 - June 2028

Conditions

  • Infertility (IVF Patients)
  • Embryo Morphokinetics
  • Progestins Primed Ovarian Stimulation

Interventions

DRUG

Progestin-Primed Ovarian Stimulation

Ovarian stimulation using progestin-primed ovarian stimulation (PPOS) protocol. Patients receive recombinant FSH starting from day 2-3 of menstrual cycle, concomitantly with oral Dydrogesterone 20mg daily to prevent premature LH surge. All embryos are cultured using time-lapse technology and cryopreserved for subsequent frozen embryo transfer.

DRUG

Antagonist protocol for IVF

Ovarian stimulation using GnRH antagonist protocol. Patients receive recombinant FSH starting from day 2-3 of menstrual cycle. GnRH antagonist is added when leading follicle reaches 12-14mm diameter to prevent premature LH surge. All embryos are cultured using time-lapse technology and cryopreserved for subsequent frozen embryo transfer.

Sponsors & Collaborators

  • Hanoi Obstetrics and Gynecology Hospital

    collaborator OTHER

  • Hanoi Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-21
Primary Completion
2028-06-30
Completion
2028-10-31

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07409493 on ClinicalTrials.gov