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Evaluate the Effectiveness of Progestin-Primed Versus GnRH Antagonist Protocols in Vietnamese Women Undergoing In-vitro Fertilization

NCT06191809 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2024-01-05

No results posted yet for this study

Summary

This study aims to evaluate the efficacy of the progestin-primed ovary stimulation (PPOS) protocol compared to the standard GnRH antagonist (GnRH\_ant) protocol across successive stages in a controlled ovarian stimulation (COS) and ICSI procedure.

Conditions

  • IVF

Interventions

PROCEDURE

Controlled Ovarian Stimulation Protocol

Ovarian Stimulation Process: * Stimulate ovaries with FSH \& hMG (150-375 IU) starting day 2-3 of menstruation. * Monitor response with ultrasound \& hormones (E2, LH, P4). * GnRH-ant arm: Prevent LH surge with Cetrorelix (0.25mg) starting day 5. * PPOS arm: Suppress LH with Dydrogesterone (10mg x 3/day) from day 1. * Trigger ovulation when ≥2 follicles \>17mm (Triptorelin, hCG, or rhCG). * Oocyte retrieval 36-38 hours later (\>10mm follicles aspirated). Embryo Culture \& Monitoring: * Fertilize with ICSI. * Culture \& evaluate embryos (43-45 hours, day 3/5). * Freeze all embryos.

Sponsors & Collaborators

  • Hanoi Medical University

    lead OTHER

Principal Investigators

  • Thach Than Trong · Hanoi Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-14
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06191809 on ClinicalTrials.gov