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Effects of Two Different Lion's Mane Extracts (Lions Mane Fruiting Body & Lions Mane Fruiting Body With Mycellium) on Cognitive Performance, Subjective Affect, Serum Biomarkers, and Gut Microbiota in Healthy Adults

NCT07405957 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 87

Last updated 2026-02-13

No results posted yet for this study

Summary

A randomized, double-blind, placebo-controlled, parallel-arm study design, of healthy men and women assigned to one of three groups: 1 gram/day of MycothriveTM Nordic origin fruiting body lion's mane (M-LM), 1 gram/day of a commercially available mycelium and fruiting body lion's mane (MFB-LM), or placebo (PL) to evaluate Lions mane potential cognitive and gut health benefits in a controlled daily dose for 45 days.

Conditions

  • Healthy Adult Females
  • Healthy Adult Male

Interventions

DIETARY_SUPPLEMENT

Lion Mane (Hericium erinaceus) fruiting body extract - Nordic Origin

This extract contains the fruiting body of the Hericium erinaceus, providing only active levels of triterpenoids and beta glucans found in the fruiting body alone.

DIETARY_SUPPLEMENT

Lions Mane (Hericium erinaceus) Fruiting body and mycelium

This extract contains both the fruiting body and the mycelium of the Hericium erinaceus, providing different levels of active triterpenoids and beta glucans than fruiting body alone.

OTHER

Maltodextrin (Placebo)

Maltodextrin (Placebo)

Sponsors & Collaborators

  • The Center for Applied Health Sciences, LLC

    collaborator INDUSTRY

  • Applied Food Sciences Inc.

    lead INDUSTRY

Principal Investigators

  • Michael B. La Monica, Ph.D., CSCS · The Center for Applied Health Sciences

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-11
Primary Completion
2025-06-27
Completion
2025-09-10

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07405957 on ClinicalTrials.gov