Biomarkers of Brain Injury in Children With Brain Tumors

Summary

The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is:

Can investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors?

Researchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers.

Participants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.

Conditions

• Brain Tumor
• Childhood Cancer
• Childhood Brain Tumor

Sponsors & Collaborators

• Region Blekinge

  collaborator UNKNOWN

• Region Dalarna

  collaborator UNKNOWN

• Region Gotland

  collaborator UNKNOWN

• Region Gävleborg

  collaborator OTHER

• Region Uppsala

  collaborator UNKNOWN

• Region Halland

  collaborator OTHER

• Region Jämtland Härjedalen

  collaborator OTHER

• Region Jönköping County

  collaborator OTHER_GOV

• Region Kalmar län

  collaborator UNKNOWN

• Region Kronoberg

  collaborator UNKNOWN

• Region Norrbotten

  collaborator UNKNOWN

• Region Skåne

  collaborator UNKNOWN

• Region Stockholm

  collaborator OTHER_GOV

• Sormland County Council, Sweden

  collaborator OTHER

• Region Värmland

  collaborator UNKNOWN

• Region Västerbotten

  collaborator OTHER_GOV

• Region Västernorrland

  collaborator UNKNOWN

• Region Västmanland

  collaborator OTHER

• Region Örebro län

  collaborator UNKNOWN

• Region Östergotland

  collaborator UNKNOWN

• Göteborg University

  collaborator OTHER

• Västra Götalandsregionen

  collaborator OTHER

• Uppsala University

  lead OTHER

Principal Investigators

• Arja Harila, MD, PhD · Uppsala University

Eligibility

Max Age

17 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-08-01

Primary Completion

2031-12-31

Completion

2031-12-31

Countries

• Sweden

Study Locations