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Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

NCT06185686 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2025-07-18

No results posted yet for this study

Summary

With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.

Conditions

  • Brain Tumor, Primary

Interventions

OTHER

Cognitive testing

NIH Toolbox Cognitive Battery and the Novel Cognitive Measure (NCM)

DEVICE

Resting State MRI/Precision functional mapping

At baseline (before the end of radiation therapy) and approximately 12 months after the completion of radiation therapy.

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • The Foundation for Barnes-Jewish Hospital

    collaborator OTHER

  • Children's Cancer Research Fund

    collaborator OTHER

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Stephanie Perkins, M.D. · Washington University School of Medicine

Eligibility

Min Age
8 Years
Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-10
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06185686 on ClinicalTrials.gov