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Short-term Effects of Broccoli-derived Glucoraphanin on Recovery From Eccentric Muscle Damage

NCT07373106 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2026-01-28

No results posted yet for this study

Summary

Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains unknown. This study aims to evaluate whether short-term supplementation with broccoli-derived glucoraphanin will improve recovery from exercise-induced muscle damage. In a randomized, double-blind, placebo-controlled crossover design, fifteen participants will consume either high-glucoraphanin broccoli powder (320 μg) or placebo for one week, followed by elbow flexor eccentric exercise and continued supplementation. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology will be measured at baseline, immediately post-exercise, and at 48 and 96 hours post-exercise.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

broccoli powder consumption

Participants underwent two separate sessions of muscle-damaging exercise targeting the elbow flexors: (1) following seven days of broccoli powder consumption (condition X), and (2) following an equivalent placebo regimen (condition Y). The broccoli supplementation consisted of 10 g of broccoli powder \[a freeze-dried glucoraphanin-rich broccoli powder (99.5% broccoli and 0.5% mustard seed)\] dissolved in 125 mL of boiling water, providing 320 μg of glucoraphanin per serving. It was consumed when still hot/warm once daily for seven days before and for four days following the eccentric exercise protocol. The placebo powder, matched in appearance and preparation, contained no broccoli-derived bioactives.

DIETARY_SUPPLEMENT

Placebo (no broccoli-derived bioactives)

The placebo powder, matched in appearance and preparation, contained no broccoli-derived bioactives.

Sponsors & Collaborators

  • Lithuanian Sports University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-15
Primary Completion
2026-03-15
Completion
2026-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07373106 on ClinicalTrials.gov