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External Validation of VVI

NCT07372664 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-09-02

No results posted yet for this study

Summary

Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation.

In this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases:

1. during pressure support ventilation with 5/5,
2. during pressure support ventilation with 8/0,
3. during t-tube or pressure support ventilation with 0/0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation.

The investigators will evaluate whether VVI can predict accurately the weaning outcome.

Conditions

  • Weaning Mechanical Ventilation

Sponsors & Collaborators

  • University of Thessaly

    lead OTHER

Principal Investigators

  • Apostolos - Alkiviadis Menis · General Hospital of Larissa

  • Demosthenes Makris · University of Thessaly

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-28
Primary Completion
2027-08-31
Completion
2027-09-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07372664 on ClinicalTrials.gov