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The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function

NCT07369830 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 156

Last updated 2026-01-27

No results posted yet for this study

Summary

This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade placement of probiotics into the distal deserted intestine during prophylactic stoma to improve bowel function after stoma reversal were evaluated through randomized controlled clinical trials.Observing the changes in gut microbiota during the prophylactic stoma period, the impact of probiotics on the structure of gut microbiota, and exploring the correlation between gut genera and bowel function after stoma reversal.

Conditions

Interventions

BIOLOGICAL

Clostridium butyricum (live) Tablets(Meiya)

Clostridium butyricum (live) Tablet administered into the dysfunctional intestine for low dose and high dose group, while control group has no intervention

Sponsors & Collaborators

  • Characteristic Medical Center of Rocket Army

    collaborator UNKNOWN

  • Zhongnan Hospital

    collaborator OTHER

  • The First Affiliated Hospital of Nankai University

    collaborator UNKNOWN

  • First Affiliated Hospital of Fujian Medical University

    collaborator OTHER

  • Ruijin Hospital

    collaborator OTHER

  • Nanfang Hospital, Southern Medical Universit

    collaborator UNKNOWN

  • Huashan Hospital

    lead OTHER

Principal Investigators

  • Xiang Jianbin, Doctor · Huashan Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-15
Primary Completion
2029-03-30
Completion
2029-06-30

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07369830 on ClinicalTrials.gov