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Mesorectal Microbiome as a Prognostic Factor in Patients With Rectal Cancer

NCT04804956 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-10-06

No results posted yet for this study

Summary

The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer.

Rectal cancer is the third most common neoplasm worldwide and the complete excision of the mesorectum is a major prognostic factor.

The identification of microorganisms in the adipose tissue that surrounds the small intestine in inflammatory diseases, together with bacterial alterations found in colonic mucosa and feces in patients with rectal cancer in comparison with healthy individuals indicates that microbiome alteration plays an essential role in pathogenesis.

The mesorectal microbiome in rectal cancer patients stills unknown and given its importance in the prognostic of the disease the goal of this study is to identify microbial profiles that allow predicting rectal cancer patients with a poor prognosis.

Conditions

Interventions

PROCEDURE

Stool sample

One stool sample will be taken at baseline for microbiota characterization

PROCEDURE

Rectal mucosa sample

Characterization of tissue microbiota before and after surgery.

PROCEDURE

Mesorectal adipose tissue sample

Characterization of tissue microbiota and dysfunction

PROCEDURE

Subcutaneous adipose tissue sample

Characterization of tissue microbiota and dysfunction

PROCEDURE

Visceral adipose tissue sample

Characterization of tissue microbiota and dysfunction

BEHAVIORAL

Dietary assessment

Dietary assessment will be taken at baseline

Sponsors & Collaborators

  • Girona Biomedical Research Institute

    collaborator UNKNOWN

  • University Hospital of Girona Dr. Josep Trueta

    lead NETWORK

Eligibility

Min Age
18 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2024-04-01
Completion
2026-04-01

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04804956 on ClinicalTrials.gov