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Prevalence of Airway Closure

NCT07368491 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2026-03-13

No results posted yet for this study

Summary

The primary objective of this study is to describe the prevalence of airway closure during the total support phase of invasive mechanical ventilation in subjects admitted to an intensive care unit (ICU). The secondary objective is to analyze whether there are clinical-demographic and/or ventilatory characteristics associated with the presence of airway closure.

Conditions

  • To Determine the Annual Prevalence of Airway Closure

Interventions

OTHER

airway closure

After setting the flow at 5 L/min and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters.

Sponsors & Collaborators

  • Romina Belen Mattei

    lead OTHER

Principal Investigators

  • Romina B Mattei · CMPFA Churruca-Visca

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2026-10-31
Completion
2026-12-31

Countries

  • Argentina

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07368491 on ClinicalTrials.gov