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Predicting High-Flow Nasal Cannula Failure Using an Electrical Impedance Tomography-Derived Index: A Multicenter Study

NCT07366541 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2026-01-26

No results posted yet for this study

Summary

High-Flow Nasal Cannula (HFNC) therapy is widely used to treat acute respiratory failure. However, predicting therapy failure remains challenging as conventional indices rely on intermittent measurements and cannot provide continuous, objective monitoring. Electrical Impedance Tomography (EIT) enables non-invasive, real-time assessment of regional lung ventilation. This study evaluated whether an EIT-derived Flow Index (FI) could predict HFNC therapy failure within 48 hours.

Conditions

  • Acute Respiratory Failure
  • Oxygen Therapy Failure
  • High-flow Nasal Cannula (HFNC) Therapy
  • Electrical Impedance Tomography (EIT)

Interventions

DEVICE

Electrical impedance tomography(PulmoVista 500, Dräger Medical)

Outcome Parameters: FI, ROX index, respiratory rate, SpO₂

Sponsors & Collaborators

  • Ruijin Hospital

    lead OTHER

Principal Investigators

  • Hongping Qu · Department of Critical Care Medicine，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-01
Primary Completion
2025-12-31
Completion
2026-02-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07366541 on ClinicalTrials.gov