Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.
NCT07365696 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 30
Last updated 2026-01-26
Summary
Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.
Conditions
- Fatigue
- Graft Vs Host Disease
- Cognitive Dysfunction
Interventions
- RADIATION
-
PET investigation
Trial subjects will undergo two advanced PET investigations
Sponsors & Collaborators
- collaborator OTHER
-
Karolinska University Hospital
lead OTHER
Eligibility
- Min Age
- 20 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-11-28
- Primary Completion
- 2027-12-28
- Completion
- 2028-12-28
Countries
- Sweden
Study Locations
More Related Trials
-
Amyloid and Tauopathy PET Imaging in Acute and Chronic Traumatic Brain Injury
NCT02266563 ·Status: COMPLETED
-
A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury
NCT03810222 ·Status: COMPLETED
-
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
NCT06624267 ·Status: NOT_YET_RECRUITING
-
Isotopic Imaging for Prodromal Alzheimer's Disease
NCT01231295 ·Status: COMPLETED
-
Intelligent Digital Tools for Screening of Brain Connectivity and Dementia Risk Estimation in People Affected by Mild Cognitive Impairment
NCT05159661 ·Status: RECRUITING
-
Identification of Predictive Neuroinflammatory Biomarkers of Neuro-radiological Evolution in Severe Traumatic Brain Injury
NCT03659006 ·Status: UNKNOWN ·Phase: NA
-
Biomarkers and Outcome 1 and 10-15 Years After Severe Traumatic Brain Injury
NCT05138692 ·Status: COMPLETED
-
PET Imaging of the Translocator Proteine Ligands (TSPO) With [18 F] DPA-714 Biomarker of NeuroInflammation in Cognitive Decline (NIDECO)
NCT02062099 ·Status: COMPLETED ·Phase: PHASE1
-
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
NCT06927063 ·Status: NOT_YET_RECRUITING
-
PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) Radioligand
NCT03958630 ·Status: TERMINATED ·Phase: PHASE1
-
Olfactory Function in Patients With Acute Mild Traumatic Brain Injury
NCT02977728 ·Status: COMPLETED
-
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
NCT06874205 ·Status: RECRUITING ·Phase: PHASE1
-
Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia
NCT02796287 ·Status: TERMINATED ·Phase: NA
-
PET-MRI Imaging in Patients With Acute Neurovascular Syndrome
NCT03215563 ·Status: COMPLETED
-
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
NCT04124029 ·Status: RECRUITING
-
Synaptic Density, Tau and Multiparametric PET-MR in Brain Trauma, Stroke and Mild Cognitive or Behavioral Impairment.
NCT03514524 ·Status: ENROLLING_BY_INVITATION ·Phase: NA
-
Trauma and Critical Care Exposure Examined With PET (TRAPETS)
NCT05245253 ·Status: UNKNOWN
-
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
NCT01353196 ·Status: COMPLETED
-
Assess Fibrin in Brains With AD/ADRD
NCT05336695 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
TBI Multimodal Monitoring Study
NCT02993549 ·Status: UNKNOWN
-
Assess 123-I IMPY and SPECT Imaging as a Tool to Detect β-Amyloid in the Brain
NCT00287248 ·Status: COMPLETED ·Phase: PHASE1
-
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
NCT03366129 ·Status: COMPLETED
-
Study of the Indications for Amyloid Positon Emission Tomography (PET) Scans and Their Usefulness for Patients With Suspected Alzheimer's Disease (AD)
NCT06467981 ·Status: COMPLETED
-
Beta-Amyloid Imaging With [18F]NAV4694 PET in Predicting Progression to AD in Subjects MCI
NCT01812213 ·Status: TERMINATED ·Phase: PHASE2
-
Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks
NCT04975139 ·Status: ACTIVE_NOT_RECRUITING