Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

Summary

RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics. This knowledge gap hinders the design of effective prevention and control strategies.

RACSMEI will improve understanding across multiple pathogens using a multidisciplinary One Health approach. We will answer key questions on burden, ecology, transmission and population immune status to inform targeted and culturally appropriate interventions. The project combines a nationally representative One Health survey, social-science methods, and multiplex, diverse diagnostics to efficiently test for 57 priority pathogens, including zoonotic and vector-borne agents, vaccine-preventable and elimination-targeted diseases, enteric, respiratory, and environmentally transmitted pathogens and selected neglected tropical diseases and parasites relevant to Cambodia.

Mathematical modelling will reconstruct and forecast transmission dynamics and assess the potential impact of future public-health strategies. By integrating intersectoral data and innovative methods, RACSMEI will generate actionable evidence for public-health authorities, support precision One Health interventions, and help reduce disease burden in affected communities. The project also aims to ensure the transferability of methods and insights to other countries facing similar challenges.

Conditions

• Meningitis
• Dengue
• Chikungunya
• Zika Virus Infection
• Japanese Encephalitis
• West Nile Virus
• Tick-borne Encephalitis (TBE)
• Severe Fever With Thrombocytopenia Syndrome
• Nipah Virus Infection
• Hantavirus Infections
• Hepatitis E
• Brucellosis
• Q Fever
• Leptospirosis
• Melioidosis
• Influenza A and B
• Malaria
• Yellow Fever
• Mayaro Fever
• Usutu Virus Infection
• Oropouche Fever
• Rift Valley Fever
• Arenavirus Infections
• Measles
• Mumps
• Rubella
• Human Papilloma Virus (HPV)
• Rotavirus Disease
• Pertussis
• Diphteria
• Tetanus
• Varicella
• Hepatitis A
• Norovirus Infections
• Enterovirus
• Adenovirus
• Rhinovirus
• Parvovirus
• Respiratory Syncytial Virus (RSV)
• Cytomegalovirus
• Epstein Barr Virus
• Salmonella Typhi
• Vibrio Cholerae
• Legionella Pneumophila Pneumonia
• Mycoplasma
• Chlamydia
• Lymphatic Filariasis
• Toxoplasma Gondii
• Giardiasis
• Entamoeba Histolytica
• Leishmaniasis
• Strongyloides Stercoralis Infection
• Ascaris Lumbricoides
• Trichuris Trichiura
• Clonorchis Sinensis
• Opisthorchis Viverrini
• Schistosomiasis
• Streptococcus Pneumoniae

Sponsors & Collaborators

• Institut Pasteur

  collaborator INDUSTRY

• CDC - Ministry of Health of Cambodia

  collaborator UNKNOWN

• UMR ASTRE (CIRAD)

  collaborator UNKNOWN

• Malaria Consortium

  collaborator OTHER

• Ministry of Agriculture, Forestry and Fisheries Cambodia

  collaborator UNKNOWN

• Institut Pasteur du Cambodge

  lead OTHER

Principal Investigators

• Claude Flamand, Ph.D. · Institut Pasteur du Cambodge

Eligibility

Min Age

2 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-12-18

Primary Completion

2026-04-16

Completion

2027-09-30

Countries

• Cambodia

Study Locations