Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases

Summary

Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments). Most of these diseases are found in certain tropical zones, but global warming and increased international trade are modifying their geographical distribution, with a gradual trend towards temperate regions. A number of these pathogens have already been detected in Occitania, including dengue fever, West Nile, leishmaniasis and Q fever. Given the region's high mosquito population and favorable climatic conditions, other zoonoses have a strong potential to appear in the region, or may already be circulating at a low level. The study focuses on 18 pathogens selected for their potential to emerge and establish themselves in the Occitanie region: Leishmaniasis, Leptospirosis, Brucellosis, Q fever, Rickettsiosis, Tularemia, Psittacosis, Lyme disease, Tick-borne encephalitis, Hantavirus, Hepatitis E virus, Dengue virus, Zika virus, Chikungunya virus, West-Nile virus, Usutu virus, Toscana virus, Crimean-Congo haemorrhagic fever virus.

The aim of the study is to find out whether patients have antibodies against these infectious agents, which would indicate that they have been exposed to them in the past, even in the absence of symptoms.

Describing the circulation of these pathogens will enable to implement appropriate public health measures to avoid the risk of epidemics (mosquito control, informing professionals, etc.), as well as to assess the risk incurred in the workplace and have this risk recognized by the healthcare system.

Conditions

• Leishmaniasis
• Leptospirosis
• Brucellosis
• Q Fever
• Rickettsiosis
• Tularemia
• Psittacosis
• Lyme Disease
• Tick-borne Encephalitis
• Hantaviral Infection Nos
• Hepatitis E
• Dengue Virus
• Zika Virus
• Chikungunya Virus Infection
• West Nile Virus
• Usutu Virus
• Toscana Virus
• Crimean-Congo Haemorrhagic Fever Virus

Interventions

OTHER

Peripheral venous blood sample

Peripheral venous blood sampling for IgG serology against leishmaniasis, leptospirosis, brucellosis, Q fever, rickettsiosis, tularemia, psittacosis, Lyme disease, tick-borne encephalitis, hantavirus, hepatitis E virus, dengue virus, Zika virus, Chikungunya virus, West Nile virus, Usutu virus, Toscana virus, Crimean-Congo hemorrhagic fever virus.

Sponsors & Collaborators

• TransVIHMI UM, IRD UMI233, Inserm U1175

  collaborator UNKNOWN

• UMR 1058 Pathogenesis & Control of Chronic & Emerging Infections PCCEI

  collaborator UNKNOWN

• University Hospital, Montpellier

  lead OTHER

Principal Investigators

• CHARLOTTE BOULLE, MD · University Hospital, Montpellier

Study Design

Allocation

NA

Purpose

SCREENING

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-03-03

Primary Completion

2025-10-03

Completion

2025-10-03

Countries

• France

Study Locations