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Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste

NCT07340944 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-01-15

No results posted yet for this study

Summary

This study aimed to evaluate the efficacy of N-acetylcysteine (NAC) used as an intracanal medicament on antibacterial activity, periapical RANKL/OPG ratio, and postoperative pain levels.

Conditions

  • Chronic Apical Periodontitis

Interventions

DRUG

N Acetyl Cysteine

NAC was placed into the root canal as an intracanal medication. The medication was removed after one week. Root canal treatment was completed. Treatment was completed for 15 patients in the group within one month.

DRUG

Calcium Hydroxide (Ca(OH)2)

Ca(OH)2 was placed into the root canal as an intracanal medication. The medication was removed after one week. Root canal treatment was completed. Treatment was completed for 15 patients in the group within one month.

DRUG

Double Antibiotic Paste

DAP was placed into the root canal as an intracanal medication. The medication was removed after one week. Root canal treatment was completed. Treatment was completed for 15 patients in the group within one month.

Sponsors & Collaborators

  • Ataturk University

    lead OTHER

Principal Investigators

  • Ceren Yeniay · Ataturk University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-10
Primary Completion
2023-01-09
Completion
2024-05-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07340944 on ClinicalTrials.gov