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Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)

NCT04837391 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2021-04-08

No results posted yet for this study

Summary

Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature mortality. Postoperative cognitive complications are also quite common in extensive oncological surgeries. In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers \[S100 β, neuron specific enolase (NSE), interleukin 6 (IL-6) and high mobility group box-1 (HMGB-1 protein)\].

Conditions

  • Postoperative Cognitive Dysfunction
  • Postoperative Delirium
  • Frailty

Interventions

DEVICE

Near Infrared Spectroscopy (NIRS)

Patients are monitored by near infrared spectroscopy before anesthesia induction until end of the operation. Graphical presentation of cerebral oxygenation during surgery evaluated by INVOS Analytics Tool Version 1.2.

DIAGNOSTIC_TEST

Blood sample

Blood samples are obtained before and after surgery. S-100, Neuron specific enolase (NSE), Interleukin-6 (IL-6), High Mobility Group Box Protein (HMGB-1) are going to be studied by ELISA method after data collection process end.

DIAGNOSTIC_TEST

Addenbrooke Cognitive Examination III (ACE-III)

ACE-III is administered to study participants one day before surgery, 1 week after surgery, and three months after surgery to diagnose postoperative cognitive dysfunction.

DIAGNOSTIC_TEST

Confusion Assessment Method

Confusion Assessment Method is administered to study participants in postoperative recovery room to diagnose postoperative delirium.

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Principal Investigators

  • Meltem Savran Karadeniz, Assoc. Prof. · Istanbul University

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-21
Primary Completion
2021-05-21
Completion
2021-07-21

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04837391 on ClinicalTrials.gov