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Preventing Muscle Loss After Bariatric Surgery: Protein-Collagen Supplementation and Resistance Exercise

NCT07303543 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2025-12-26

No results posted yet for this study

Summary

The aim of this clinical trial is to investigate the effectiveness of collagen, considered a new approach to prevent muscle mass loss after bariatric surgery, and to demonstrate the relationship between this effect and exercise. The key questions it aims to answer are:

Does whey protein supplementation with collagen combined with resistance exercise prevent muscle mass loss after bariatric surgery? Do whey protein supplementation with collagen combined with resistance exercise affect fat mass after bariatric surgery?

Researchers will compare collagen with whey protein.

The study groups and interventions to be implemented are summarized below:

Group 1: Control Group (CG; n: 10) Whey protein supplementation will be administered Vitamin and mineral supplementation will be administered No resistance exercise will be performed The participants will eat according to bariatric surgery nutrition guidelines and perform physical activities.

Group 2: Whey Protein + Collagen + Exercise Group (WPCEG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

They will begin a resistance exercise program 4 weeks after surgery.

Group 3: Whey Protein + Collagen + No Exercise Group (WPCG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. No resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

Group 4: Whey Protein + Exercise Group (WPEG; n: 10) Whey protein supplements will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.

A resistance exercise program will begin at 4 weeks post-operatively.

Conditions

  • Bariatric Surgery
  • Muscle Loss

Interventions

DIETARY_SUPPLEMENT

Whey protein supplement

Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.

DIETARY_SUPPLEMENT

Hydrolyzed Collagen Supplement

Oral hydrolyzed collagen supplement provided daily in combination with whey protein.

DIETARY_SUPPLEMENT

Vitamin and Mineral Supplementation

Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.

BEHAVIORAL

Resistance Exercise Program

Structured resistance exercise program initiated at postoperative week 4, supervised, 3 times per week.

Sponsors & Collaborators

  • Medipol University

    lead OTHER

Principal Investigators

  • Halit E Taşkın, Dr. · Cerrahpaşa Faculty of Medicine, General Surgery

  • Nihal Z Erdem, PhD · Istanbul Medipol University, Nutrition and Dietetics

  • Bürke Köksalan, PhD

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-02
Primary Completion
2025-12-20
Completion
2026-01-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07303543 on ClinicalTrials.gov