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Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain

NCT07285980 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2025-12-26

No results posted yet for this study

Summary

The goal of this clinical trial was to evaluate methods to prevent pain on intravenous administration of propofol during induction of anesthesia. Propofol frequently causes a burning or painful sensation when injected into a peripheral vein.

This randomized study compared three approaches in adult patients scheduled for elective surgery: propofol alone (control), propofol with 40 mg lidocaine mixed directly, and a brief intravenous lidocaine under venous occlusion (Bier block) using 40 mg for 2 minutes before propofol.

The primary outcome was the incidence of pain on propofol injection measured with a 4-point verbal rating scale (0 = no pain to 3 = severe pain). Secondary outcomes included pain intensity, peri-induction hemodynamic parameters, and local injection-site adverse effects.

Conditions

  • Propofol Injection Pain

Interventions

DRUG

propofol

Intravenous anesthetic used for induction of anesthesia at a dose of 2 mg/kg.

DRUG

Lidocaine - Propofol Mixture

40 mg lidocaine mixed directly with propofol prior to intravenous injection to reduce injection pain.

DRUG

Lidocaine - Bier Block

40 mg lidocaine injected intravenously under venous occlusion for 2 minutes before propofol administration.

Sponsors & Collaborators

  • Asma Ladib

    lead OTHER

Principal Investigators

  • Asma Ladib, MD · Maternity and Neonatology Center of Monastir, Dept of Anesthesiology and Critical Care B

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-07-31
Completion
2025-07-31

Countries

  • Tunisia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07285980 on ClinicalTrials.gov