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Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain

NCT07116304 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-08-11

No results posted yet for this study

Summary

Propofol is the most popular IV anaesthetic agent used for induction, however one of its known side effects is causing pain on injection, the gold standard method in preventing this pain is using lidocaine prior to injecting propofol. multiple drugs have been investigated to reduce the aforementioned pain, however there has been no study comparing lidocaine to parecoxib, an NSAID.

Conditions

  • Preventing Propofol Pain on Injection

Interventions

DRUG

Lidocaine, a local anaesthetic.

it will be given as a pretreatment prior to injection of propofol, with a tourniquet applied.

DRUG

Parecoxib 40mg

atients in this group will receive IV parecoxib 40 mg (the standard full dose for an adult) diluted to a total volume of 5 mL with normal saline.

Sponsors & Collaborators

  • Oman Medical Speciality Board

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2026-12-30
Completion
2026-12-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07116304 on ClinicalTrials.gov