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Preventing Propofol-associated Injection Pain

NCT00864682 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 156

Last updated 2021-01-27

Study results available
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Summary

Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.

Conditions

Interventions

DRUG

Saline

3.3 mL normal saline

DRUG

Lidocaine / propofol admixture

lidocaine 50 mg plus propofol 50 mg intravenous (iv)

DRUG

lidocaine pretreatment

lidocaine 50 mg iv under tourniquet-control

Sponsors & Collaborators

  • Benaroya Research Institute

    lead OTHER

Principal Investigators

  • Joseph M Neal, MD · Virginia Mason Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2009-03-31
Completion
2009-04-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00864682 on ClinicalTrials.gov