The EAT-FIBRE Study.

Summary

The goal of this clinical trial is to understand whether diet can impact mechanisms linked to early-onset colorectal cancer.

The main question it aims to answer is: does a high-fibre modified EatWell diet improve stool, blood, urine, and saliva measures linked to early-onset colorectal cancer, compared to the standard EatWell diet?

Researchers will compare the standard EatWell diet (UK national healthy eating guidance providing 30g/day of dietary fibre) to a modified EatWell diet (UK national healthy eating guidance plus specific thresholds for fibre-rich food groups providing 40g/day of dietary fibre).

Participants will follow the dietary advice for 12 weeks, attend clinic visits at the start and end of the study for stool, blood, urine, and saliva sampling, body composition measures, health checks, and complete health, diet, and lifestyle questionnaires.

Conditions

• Microbiome Related Mechanisms Linked to Early Onset Colorectal Cancer

Interventions

OTHER

Modified EatWell diet

5-a-day for fruits and vegetables, \<70g/day of red meat, 2 portions of fish/week (one of which is oily), \<14 units of alcohol/week, plus specific daily thresholds of 180g/day (cooked) of wholegrain cereals, 160g/day (cooked) of beans and pulses, and 30g/day of nuts and seeds. Total dietary fibre = 40g/day.

OTHER

EatWell diet

5-a-day for fruits and vegetables, \<70g/day of red meat, 2 portions of fish/week (one of which is oily), and \<14 units of alcohol/week. No specific daily thresholds for wholegrain cereals, beans and pulses, or nuts and seeds will be provided. Total dietary fibre = 30g/day.

Sponsors & Collaborators

• Cancer Research UK

  collaborator OTHER

• National Cancer Institute (NCI)

  collaborator NIH

• Bowelbabe Fund

  collaborator UNKNOWN

• National Cancer Institute, France

  collaborator OTHER_GOV

• King's College London

  lead OTHER

Principal Investigators

• Jordana Bell, Professor · King's College London Twin Research & Genetic Epidemiology

• Sarah Berry, Professor · King's College London Department of Nutritional Sciences

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-01-31

Primary Completion

2027-10-31

Completion

2027-12-31

Countries

• United Kingdom

Study Locations