Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss

Summary

The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted reproductive technology (ART). Despite medical advances, some patients repeatedly fail to achieve pregnancy, or experience repeated miscarriages. These situations may be linked to subtle immune or microbial disturbances in the uterus. This study seeks to identify immune and microbiological profiles in the endometrium during the implantation window-a crucial period when the embryo attaches to the uterine wall. We will compare women who have experienced RIF and/or RPL with women who have had no such history. Blood and uterine samples will be analyzed to investigate whether certain immune or microbial features are associated with these reproductive failures. The ultimate goal is to uncover predictive factors that may explain why some women experience implantation failure or pregnancy loss, and to lay the foundation for future personalized treatments to improve reproductive outcomes.

Conditions

• Recurrent Implantation Failure
• Recurrent Pregnancy Loss
• Infertility, Female
• Endometrial Diseases
• Endometritis
• Endometriosis
• Adenomyosis

Interventions

DIAGNOSTIC_TEST

Endometrial Biopsy

Endometrial biopsy with Cornier Pipelle (part of the treatment in the RIF/RPL group and some patients of the control group / added for the research for the other patients of the control group)

DIAGNOSTIC_TEST

Vaginal Swab

Vaginal sample collection using a cotton swab. Part of the treatment

DIAGNOSTIC_TEST

Blood sample

Peripheral blood draw. Part of the treatment + 10 mL additional for research

DIAGNOSTIC_TEST

Pelvic ultrasound (±pelvic MRI)

Pelvic ultrasound (±pelvic MRI). Part of the treatment

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator OTHER_GOV

• ADREGOF

  collaborator UNKNOWN

• URC-CIC Paris Descartes Necker Cochin

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Mathilde Bourdon, MD, PhD · Service de Gynécologie Obstétrique II et Médecine de la Reproduction - Cochin Hospital

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

35 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-30

Primary Completion

2029-04-30

Completion

2031-04-30

Countries

• France

Study Locations