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Immune Cell Populations in the Endometrium

NCT06826365 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-03-19

No results posted yet for this study

Summary

Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood. In ovulatory cycles, changes occur in the populations of uterine lymphocytes, which may influence the receptivity of the endometrium and the implantation of the embryo. Particularly notable are the changes in natural killer (NK) cells, which reach their peak during the luteal phase and regulate the invasion of the trophoblast. The dominant NK cells exhibit a CD56bright phenotype and differ in cytokine profiles from peripheral blood cells. Cyclical changes also affect macrophages and T lymphocytes; however, it is unclear whether their proportions differ in women with reduced fertility. There is a need to investigate how the composition of lymphocytes in blood influences the populations in the endometrium. The aim of this study is to analyze the correlation between peripheral and endometrial lymphocytes in women with idiopathic infertility and recurrent miscarriages, compared to fertile women.

Conditions

  • Infertility, Female
  • Recurrent Miscarriage
  • Gynecologic Disease

Interventions

DIAGNOSTIC_TEST

Percentage distribution of immune system cells in peripheral blood

Assessment of the percentage distribution of the immune system cell population in peripheral blood by flow cytometry

DIAGNOSTIC_TEST

Percentage distribution of immune system cells in endometrium

Assessment of the percentage distribution of the immune system cell population in endometrium by flow cytometry

Sponsors & Collaborators

  • Jagiellonian University

    lead OTHER

Principal Investigators

  • Kazimierz Pityński, Prof., PhD · Jagiellonian University

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06826365 on ClinicalTrials.gov