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Metabolic Fluid Responsiveness in Children

NCT07255469 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-12-01

No results posted yet for this study

Summary

The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.

Conditions

  • Circulatory Failure / Shock State
  • Fluid Therapy

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Julien GOTCHAC, MD · CHU de Bordeaux - Hôpital Cardiologique Haut Lévêque

Eligibility

Min Age
0 Days
Max Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-21
Primary Completion
2027-03-21
Completion
2027-04-18

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07255469 on ClinicalTrials.gov