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Muscle Synergies in Pain and Pain Anticipation

NCT07251387 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2025-11-26

No results posted yet for this study

Summary

This study investigates how the anticipation of pain affects muscle synergies. Two groups will be compared: an experimental group, who first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively labeled as capsaicin, against a control group, who are presented with a harmless cream labeled as potentially painful, without any prior painful experience. The changes in muscle synergies will be measured during walking tasks.

Conditions

  • Pain
  • Nocebo Effect
  • Pain Anticipation

Interventions

OTHER

Pain expectation conditioning

Participants receive a neutral cream with no real harmful effects with verbal and behavioral suggestions that it may cause localized pain. Researchers wear gloves during application and emphasize the potential discomfort, stating effects may intensify with movement.

OTHER

Gait assesment

Gait will be assessed both before and after cream application. Each assessment will consist of walking on a treadmill at varying speeds while physiological data (EMG) is recorded. Identical questionnaires (VAS, TAMPA, and PCS) will be administered immediately following the first gait assessment.

Sponsors & Collaborators

  • Mitacs

    collaborator INDUSTRY

  • Universite de Picardie Jules Verne

    lead OTHER

Principal Investigators

  • Thierry Lelard, PhD, HDR · Lecturer

  • Maryne Cozette, PhD, Lecturer · Lecturer

  • Guillaume Léonard, PhD, Lecturer · Lecturer

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-01
Primary Completion
2026-02-01
Completion
2026-04-01

Countries

  • Canada
  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07251387 on ClinicalTrials.gov