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Respiratory Infections in Young Children

NCT07249996 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1088

Last updated 2025-11-25

No results posted yet for this study

Summary

The goal of this observational study is to learn about the causes, severity, and long-term effects of respiratory tract infections (RTIs) in young children from birth to five years of age in Colombia and Panamá. The main questions it aims to answer are:

How often do respiratory infections occur in children under two years old, and which viruses or bacteria cause them? Why do some children develop more severe infections than others? Do early infections or vaccinations change how the immune system responds to future illnesses? How do viruses and bacteria interact in the respiratory tract to influence disease severity and long-term respiratory health? Researchers will follow newborns from birth until age five to understand how respiratory infections develop and affect children's health over time. Participants will not receive any experimental treatment.

Families who join the study will:

Be contacted twice a week through a phone app or phone calls to check for symptoms of respiratory infection.

Attend in-person visits if their child becomes ill and every six months for routine follow-up.

Provide nasal and blood samples during illness episodes so researchers can identify the viruses or bacteria causing infection and study how the immune system responds.

This study began in May 2024 and is being conducted in Cali, Colombia, and Panamá City, Panamá. The research team plans to continue to include participants and continue active follow-up until the children reach five years of age.

The information collected will help scientists and health professionals understand how different pathogens cause respiratory infections, what factors increase the risk of severe illness, and how early infections may influence long-term lung health. The study's findings will support future efforts to prevent and treat respiratory diseases in young children.

Conditions

  • Respiratory Tract Infections (RTI)
  • Lower Respiratory Tract Infection (LRTI)
  • Viral Infections
  • Cohort Study

Sponsors & Collaborators

Principal Investigators

  • Eduardo Lopez-Medina, MD, MSc · Centro de Estudios en Infectologia Pediatrica, CEIP

Eligibility

Max Age
29 Days
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-02
Primary Completion
2031-05-02
Completion
2031-12-30

Countries

  • Colombia
  • Panama

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07249996 on ClinicalTrials.gov