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To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children

NCT06902194 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2025-03-30

No results posted yet for this study

Summary

The goal of this observational study is to answer a few questions about respiratory tract infections in South African children:

1. How do children with COVID-19 and other respiratory (chest, throat, ear or nose) germs show symptoms? What signs should be looked for, and which children are more likely to get seriously ill? Are there any new germs that haven't been discovered yet? Can immune cells in saliva predict which children will get more severe disease?
2. The body's immune response (soldier- cells) in blood and saliva (spit) will be studied.
3. What is the short-term effect of COVID-19 and other respiratory viruses/ germs on the breathing (lung function) of children?
4. What is the impact of respiratory germs on the quality of life in children and their families? The investigators aim to recruit a minimum of 250 children with respiratory pathogens.

Conditions

  • Respiratory Tract Infections (RTI)
  • Mucosal Immunity

Sponsors & Collaborators

Principal Investigators

  • Marieke van der Zalm, PhD · Desmond Tutu TB Centre

Eligibility

Max Age
13 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-23
Primary Completion
2025-11-01
Completion
2025-11-30

Countries

  • South Africa

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06902194 on ClinicalTrials.gov