MedTrace Logo

Inflammatory Mediators Associated With Infection by Respiratory Syncytial Virus

NCT03757429 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 31

Last updated 2022-05-31

No results posted yet for this study

Summary

Infection with human respiratory syncytial (RS) virus is the most common cause of hospital stay due to pediatric lower respiratory tract infection. An exaggerated immune response contributes to the pathogenesis and small children may have over reactive airways for a long time after an infection.

New research has shown that polymorphonuclear leukocytes (PMNs) are stimulated by the virus. Besides fighting the infection they also cause collateral damage to the host. Among other mechanisms PMNs stimulates mucus formation that affects breathing. They also secrete enzymes, toxic proteins and free radicals that may cause harm to lung tissue and airways.

The current project strives towards identifying and quantifying inflammatory mediators in sputum, urine and blood of children with severe RS-virus infection. The ultimate aim of the project is to, in detail, describe proteins contributing to the pathogenesis of the disease.

Conditions

  • Respiratory Tract Infections
  • Respiratory Syncytial Virus Infections

Interventions

OTHER

RS-virus infection

The intervention consists of lower respiratory tract infection due to RS-virus

Sponsors & Collaborators

  • Swedish University of Agricultural Sciences

    collaborator OTHER

  • Uppsala University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-01
Primary Completion
2022-04-01
Completion
2022-04-01

Countries

  • Sweden

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03757429 on ClinicalTrials.gov