Impact of Congenital Heart Disease on the Prognosis of Childhood Hematological Neoplasms: A Multicenter Cohort Study

Summary

This study aims to determine whether congenital heart disease increases chronic health risks and mortality in childhood hematological tumor survivors, explore potential shared genetic factors between these conditions, identify other factors affecting long-term outcomes and quality of life, and validate any discovered genetic links through mechanistic investigations.

Conditions

• Congenital Heart Disease (CHD)
• Hematologic Malignancy

Sponsors & Collaborators

• Nanjing Children's Hospital

  collaborator OTHER

• Children's Hospital of Suzhou University

  collaborator UNKNOWN

• Tongji Hospital

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Guangzhou Women and Children's Medical Center

  collaborator OTHER

• Wuhan Children's Hospital

  collaborator OTHER

• Union Hospital of Huazhong University of Science and Technology

  collaborator UNKNOWN

• The Third Xiangya Hospital of Central South University

  collaborator OTHER

• Inner Mongolia Maternal and Child Health Care Hospital

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Beijing Children's Hospital

  collaborator OTHER

• Northwest Women's and Children's Hospital, Xi'an, Shaanxi

  collaborator OTHER

• Shanxi Provincial Maternity and Children's Hospital

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• Shanghai Children's Hospital

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Hebei Medical University Fourth Hospital

  collaborator OTHER

• Children's Hospital of Fudan University

  lead OTHER

Eligibility

Min Age

0 Weeks

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-02-15

Primary Completion

2025-11-10

Completion

2025-11-10

Countries

• China

Study Locations