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The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis.

NCT07246577 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 340

Last updated 2026-04-15

No results posted yet for this study

Summary

Giant cell arteritis (GCA) is the most common vasculitis in the elderly and is usually treated with long-term corticosteroid therapy. Many patients experience relapses and treatment-related side effects. Current diagnostic and monitoring methods provide limited prognostic information and cannot reliably distinguish active from inactive disease during relapse. This project addresses the clinical need for improved tools to identify patients at high risk of relapse and to develop more effective methods for disease monitoring.

The aim is to develop new tools that enable more personalized treatment of GCA. By combining vascular ultrasound with novel blood biomarkers, we seek to predict disease course and relapse risk. The specific objectives are:

* To identify ultrasound and blood biomarkers that can predict long-term disease control.
* To determine which ultrasound parameters and blood biomarkers can distinguish active from inactive disease during treatment.
* To evaluate whether extended vascular ultrasound protocols can improve diagnostic accuracy.

The ultimate goal is to establish safe, practical tools for improved diagnosis and follow-up in patients with GCA.

Conditions

  • Giant Cell Arteritis (GCA)

Sponsors & Collaborators

  • Vastra Gotaland Region

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2029-12-01
Completion
2029-12-01

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07246577 on ClinicalTrials.gov